AST Surgical Technologist Practice Exam

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Which of the following solutions should be used to prep the donor site for a split-thickness skin graft?

Chlorhexidine
Iodine
Alcohol
Betadine

The correct answer is: Chlorhexidine

Using chlorhexidine as a prep solution for the donor site in a split-thickness skin graft is appropriate due to its broad-spectrum antimicrobial activity and residual effect, which helps reduce the risk of infection. Chlorhexidine is effective against both gram-positive and gram-negative bacteria, making it a reliable choice for preparing the skin. It also has the advantage of providing lasting protection after application, which is essential in a surgical setting where the area will be exposed during the grafting procedure. Other solutions, such as iodine and alcohol, might also be used in certain situations, but they have limitations. Iodine can sometimes lead to allergic reactions or skin irritation in sensitive patients, and there are concerns about staining and tissue toxicity, especially in sensitive areas or large surfaces. Alcohol, while effective at killing microorganisms, evaporates quickly and does not offer the same residual antimicrobial effects as chlorhexidine, leaving the area vulnerable to contamination after cleaning. Betadine, which is a povidone-iodine solution, shares similar concerns as iodine regarding potential allergic reactions and skin irritation. These characteristics highlight why chlorhexidine is often preferred for prepping donor sites in skin graft procedures.